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![]() The cockroaches take off with the key to Oggy’s fridge and dash down to the center of the Earth. But in his megalomania, Jack has found nothing better to build than a.skyscraper! Let's skip the fact that Oggy is afraid of heights and is also a sleepwalker. Jack has invited Oggy to visit the construction site of his future home sweet home. The roaches as usual are more than willing to lend a hand! The house looks like it's been blitzkrieged.A cup of coffee and let's turn over a new leaf and get this place in order. This morning Oggy wakes up, depressed and yawning. Oggy ignores the chase scene that is going on right under his nose… Jack is preparing his favorite frozen fish sticks and the roaches, never ones to slack off where food's concerned, are on the spot. But the roaches are taking a nap in the CD player… They very quickly realize how profitable it can be for them if they take over the controls of his brain. How not to succumb to the call of the fry? For the cockroaches, the temptation is too strong!Ĭoming back from the market, Oggy finds his house completely ransacked by the cockroaches: it’s a total dump! It’s just too much! He decides to protect his fridge against the “roachy” attacks and clamps on a solid lock!īy chance one day, the roaches find themselves scrambling through the labyrinth of Jack's (minuscule) brain. Oggy prepares a large plate of French fries, as golden and crunchy as one could wish for. The jealous cockroaches do everything they can to steal them and gobble them down… In a militaristic madness to get the box back, Jack only manages to destroy Oggy’s house… Oggy gets a box of chocolates for his birthday. Oggy tries to defend his refrigerator from the Cockroaches. This is the list of episodes from Season 1. ![]() In this season, the show introduces and covers the life of a blue cat named Oggy and his three enemies, the cockroaches Dee Dee, Marky and Joey. The first season of Oggy and the Cockroaches aired from 1997 until 1999. My daughter is now a very confident 11-year-old, with an abrasive, fascinating, brilliant personality all her own. Most importantly, they learned that a ‘why-the-fuck-do-you-get-a-say-in-my-life?’ attitude is a lived, and livable, attitude. They loved feeling the shape of their mom’s skull. When I got home with a shaved skull, my kids were astounded. That was the motivation for my first head shave, right there: showing my daughter that who we are, how beautiful we feel, doesn’t depend on the state or style of our hair. When I told her all forms of hairstyles could be beautiful, including being bald, she looked at me with great scepticism. I gave her the usual recommended spiel: it’s about inner beauty, there are different forms of external beauty, don’t let anyone else define you. Now, of course, my daughter is gorgeous (all our daughters are). So my kid was convinced she wasn’t beautiful. old daughter came home from preschool one day, distraught that her hair wasn’t long, curly and blonde apparently the girls in her preschool had decided that this was an important part of being beautiful. ![]() It’s awakening. I wanted to do during this lockdown but instead gave myself an almost buzz cut. Will I do it again.Totally! And all for that first shower of cold water on a freshly shaved bald head, you feel every mm. Probably this old connection to widows being asked to shave their hair as it make them undesirable. A bald head isn’t permanent and yet people are so worried or paranoid about this loss of so called beauty. My father liked it so much that he was inspired to shave his hair too but at that time, we were traveling remotely, far from a safe barber, so decided against it. ![]() It’s important to remember to brand your resume before applying to each new position for more information on branding check out my recent article 5 Key Areas to Target When Branding Your Resume. So it’s up to you to decide if increasing your networking opportunities in this way will be effective for your job search. Remember, once you proclaim yourself as an open networker, you’re opening yourself up to hundreds (or potentially thousands) of networking opportunities. ![]() Please connect with me using my e-mail address: then stating it in your LinkedIn Summary and Headline.Īnother way is to join a LION group within LinkedIn by searching “Lion” or “open networkers” under the Groups option in the site’s search engine. First, you can brand yourself as a LION by typing “I am a LinkedIn Open Networker :: LION. If you’re interested in becoming a LION, there are a number of ways to do so. But after x number of connections, LinkedIn displays only that you have “500+ connections”, meaning this motive doesn’t always work. Headhunters can’t determine the value you place on your professional connections or decide which to focus on as they determine who values their relationships with you.Īlso, keep in mind that many people sign up as LIONs knowing that connecting with thousands of people will look impressive. As Porsche celebrates three decades of enduring passion in Thailand, the marque marries German precision engineering with local heritage to create a truly unique offering: the bespoke Porsche 911 Carrera GTS 30 Years Porsche Thailand Edition. Reduce your ability to form meaningful professional relationships with a select few. Receive hundreds of e-mails from people you don’t know-including spammers. Increase your chances of acquiring a higher ranking in search results due to more connections. Expand the number of people you can network with, even if you don’t formally connect with them. Broaden your list of contacts from dozens to thousands over a short period of time. But there are both pros and cons to taking this step. With LinkedIn allowing each member to have up to 30,000 connections, becoming a LION presents an opportunity to meet thousands of professionals around the world. This creates limits on the number of people who can become your connection.īut by becoming a LinkedIn Open Networker, you open the possibility of expanding your connection base by quickly increasing the number of people in your network. Under most circumstances, when you sign up for a LinkedIn account, you are placed into a network-according to your location and possibly your school and professional affiliations. ![]() In other words, they are open to connecting with anyone who sends an invitation to them. A questo proposito, LinkedIn mette a disposizione la funzione LinkedIn OPEN TO WORK. The LinkedIn Open Networker is a member of the professional social networking site that encourages connections from any member of the site by publicly declaring they are open networkers. Per cominciare, puoi decidere a chi far sapere che sei alla ricerca di un impiego. One possibility that many seekers don’t know about is LION, or the LinkedIn Open Networker. When endeavoring to conduct a successful job search, it’s a good idea to be open to the many networking opportunities available. ![]() Instead, it allows you to run a few simple commands in the Terminal to perform the same operations. It eliminates the need to download and run an installer to install programs or manually move the app to the bin to uninstall them. Homebrew greatly simplifies the installation, updation, and uninstallation of macOS programs and utilities on Mac. ![]() Install and Manage macOS Packages on Mac Easily With Homebrew Open the Terminal and run this command to execute the Homebrew uninstallation script:Įnter y and press Return when prompted to confirm the uninstallation of Homebrew on your Mac. Uninstalling Homebrew on Mac is easy and requires you to run the Homebrew uninstallation script. Uninstalling Homebrew on Macįor some reason, if Homebrew isn’t working properly, or you no longer want it on your Mac, you can simply uninstall Homebrew from your Mac. Additionally, you can also update and uninstall packages using appropriate commands in the Terminal.Ĭheck out our Homebrew guide to learn how to use Homebrew for installing, updating, and uninstalling packages on Mac. With Homebrew installed, you can now use it to find and install various macOS programs and utilities on your Mac. If it doesn’t, you need to go over the installation process again. If this returns a path, it means the installation was successful. If you wish to confirm this, open the Terminal and run: Once the installation is complete, you’ll see a confirmation box stating that the software was installed. This may take a while, depending on your internet speed, to download and install the Xcode Command Line Tools. When prompted with a dialog box to confirm the installation, click on the Install button. Enter the following command and hit Return:.However, if you don’t have Xcode Command Line Tools on your Mac, here’s how to install it: If you’re a developer who works on apps for any of these platforms, you’d already have Xcode installed on your Mac in which case, you’ll also have the Xcode Command Line Tools and can, therefore, skip to the next step. Xcode is a macOS IDE that allows you to create macOS, iOS, iPadOS, watchOS, and tvOS apps. Next, follow the steps below to install Homebrew on your Mac. Homebrew Requirements:īefore you dive into the installation process, ensure your Mac has: It’s easy to install on Mac and involves running a few simple commands inside the Terminal app. Homebrew is compatible with both Intel and Apple Silicon CPUs. Similarly, another benefit of Homebrew is that it removes all the files associated with a program when you uninstall it to reduce clutter. One of the biggest advantages of using Homebrew is bulk package operation (installation, updation, and uninstallation), which comes in handy when you want to install/update/uninstall multiple packages at once. Using Homebrew, you can install, update, uninstall and manage various CLI and GUI software and utilities on your Mac with the help of a few simple commands. For instance, you can use Homebrew to install CLI tools like Git, Hexedit, Emacs, Vim, etc., along with GUI-based programs like Atom, Chrome, Bitwarden, etc. It’s free, open-source, and accessible from the command line (aka the Terminal app on macOS). Homebrew is a macOS package manager that facilitates the installation, updation, and deletion of various macOS programs and utilities on Mac. How do I know if I have Homebrew installed on my Mac?.Is Homebrew installed on Mac by default?.Install and Manage macOS Packages on Mac Easily With Homebrew. ![]()
![]() ![]() Gabriel has been ever-present in the Gunners' defence this season as they continue their Premier League title race with Manchester City.Īrsenal's attack has been reinforced in the past two transfer windows following the arrivals of Gabriel Jesus and Leandro Trossard. ✅ You should now have access to your previous data, and you may start using the app on your new device.Ī screenshot of your App Store subscription or purchase receipt (with date and amount visible)Ī PayPal email for the refund (required because we do not have access to the App Store payment)Arsenal defender Gabriel Magalhaes has been impressed by Napoli star Victor Osimhen this season as the Brazilian sent the striker a message on social media. ( If you no longer have access to your iOS, we can still carry on, but there is a chance you may have to start your journey all over again).Ĭancel the auto-renewal of your subscription through your Apple App Store - tap here, to learn how. Once this is completed, you can request a prorated refund for the remainder of your original subscription.īack up your progress on your iOS device - tap here, to learn how. ![]() To transfer a subscription created through the Apple App Store to an Android device, you will first need to create a new subscription through the Fabulous Website. Transfer from an Apple to an Android device Note: We only issue refunds when the remaining duration of the prior membership exceeds 1 month.ģ. The email address used to register for the new Web subscription The email/Google Account associated with the Google Play Store subscription In the description field, provide us with: Subject = Partial refund following a transfer of subscriptions Please use the "Submit a ticket" button at the bottom of this page, and enter the following information: Once all the above steps are completed, you may request a prorated refund to compensate the remainder of your original subscription. To restore your journey progress, ensure you are signed in using the email noted at step 2, then tap on the Profile icon (from the Fabulous homepage) > Settings > Premium > Restore Journey Progress. Tap the link, and you should now be connected to your new Premium subscription in the Fabulous app. It is mandatory to use the same email.Īfter successfully signing up, you will receive a “Magic Link” in your inbox. This is the email used to store your progress.Ĭancel the auto-renewal of your subscription through your Google Play Store - tap here to learn how.įrom your mobile device, click the following link to start a new web subscription using the email you noted in step 2. Tap on the Profile icon (from the homepage) > Settings > scroll down to view the Account email. Note down which email you are using with your Fabulous account. ![]() (If you no longer have access to your Android, we can still carry on, but there is a chance you may have to start your journey all over again). The process consists of 7 steps, detailed below:īack up your progress on your Android device - tap her e to learn how. Once this is completed, you can request a prorated refund for the remainder of your original subscription. To transfer a subscription created through the Google Play Store (Android) to a device with a different operating system (iOS), you will first need to create a new subscription through the Fabulous Website. Transfer from an Android to an Apple device ✅ You should now have access to your previous data, and you may start using the app on your new device.Ģ.
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The Deep Web, the Dark Web, and tools such as Tor hold mass appeal due to their secretive natures. Some are looking for something in particular that simply can’t be sourced on the regular internet, others are simply curious. Today, countless internet users try to gain entry into the Deep Web and the Dark Web. ( REMEMBER DARK WEB IS VERY SCARY MARKET PLACE ) THE FINAL WORD: THE DEEP WEB AND THE DARK WEB You should also use an anonymous email account. ![]() Don't use your personal details and try not to send to anyone.Basically shut down all the apps that are on your computer.you should put a tape over your webcam & mic too, because you just never know.Some people say it's best not to change the window size while in Tor as the authorities can track you easier if you do.Things to be considered while browsing the Dark Web. onion sites in hidden wiki so you can directly access the. This will tell how to access most things in the dark web. You might also go to the popular databases. If you want visit marketplaces simply find a darkest market list. ![]() Go to google -> download tor browser ( ) -> Install in your machine
miRNA coding transcripts are initially transcribed by RNA polymerase II as long primary miRNAs (several hundred nucleotides long) with a 5′ guano-sine cap and a 3′ polyadenylated tail. Based on current knowledge, it can be stated that genomic regions capable of generating mature functional miRNAs can be present on diverse locations within the genome.Ī general overview of the steps involved in miRNA biogenesis is illustrated in Fig. ![]() 147 Since this is a rapidly evolving field, there is potential for future developments to significantly overhaul the current understanding of miRNA genesis. 147 The rest are mostly located in the introns of coding genes and are generally cotranscribed with their host genes and processed separately. 86, 90 It is estimated that approximately 50% of miRNAs are expressed from non– protein coding transcripts. 143 Clusters of miRNA genes that coex-press polycistronically with the potential to be transcribed as a single unit were also discovered. Earlier studies had revealed 2 distinct classes of miRNAs: those that originated from overlapping introns of protein coding transcripts and others that are encoded in exons, underscoring the complexities associated with miRNA maturation. MiRNA genes can vary widely in their location in the genome. The biological significance of a vast majority of annotated miRNAs, however, remains unknown and requires functional validation. 53, 55 The current release (miRBase 20) contains 24 521 entries representing hairpin precursor miRNAs that express 30 424 mature miRNA products in 206 species. An miRNA registry, named miRBase, set up in 2002 serves as the primary online repository for all potential miRNA sequences, annotation, nomenclature, and target prediction information. This resulted in the discovery of multiple miRNAs across different species of plants and animals. The recognition and confirmation of the existence of these small RNAs, now termed microRNAs (mi-RNAs), led to intense research aimed at identifying new members of this family. 9 Many were found to be evolutionarily conserved across species and exhibited cell-type specificity. These RNAs were noncoding, around 19 to 24 nucleotides in length, and derived from a longer precursor with a stem-loop or fold-back structure. 133 The period that followed was marked by a deluge of information wherein multiple laboratories cloned numerous small RNAs from humans, flies, and worms. 141, 159 More importantly, homologues of this gene were subsequently discovered in many other organisms, including humans. In 2000, 2 separate groups discovered that a small RNA, let-7, was essential for the development of a later larval stage to adult in C. This novel mode of regulating gene expression was first thought to be a phenomenon exclusive to C. These 2 studies together brought forth a model wherein base pairing occurred between multiple lin-4 small RNAs to the complementary sites in the 3′ UTR of lin-14 mRNA, thereby causing translational repression of lin-14 and subsequent progression from L1 to L2 during C. ![]() The binding between these complementary regions decreased LIN-14 protein expression without causing any significant change in its mRNA levels. Later this group, 93 along with Wightman et al, 183 found that the smaller RNA had antisense complementarity to multiple sites in the 3′ UTR of lin-14 mRNA. The longer sequence formed a stem-loop structure and served as a precursor for the shorter RNA. Instead, it gave rise to 2 small RNAs approximately 21 and 61 nucleotides in length. Interestingly, the transcribed lin-4 was not translated into a biologically active protein. Furthermore, the downregulation of LIN-14 was found to be dependent on the transcription of a second gene called lin-4. ![]() In these organisms, the downregulation of LIN-14 protein was found to be essential for the progression from the first larval stage (L1) to L2. miRNAs were discovered in 1993 by Lee and colleagues 93 in the nematode Caenorhabditis elegans. Follow-up studies also revealed that in addition to repressing translation, miRNA binding to its target mRNA also triggered the recruitment and association of mRNA decay factors, leading to mRNA destabilization, degradation, and resultant decrease in expression levels. They primarily function by binding to complementary target sequences in messenger RNA (mRNA) and interfering with the translational machinery, thereby preventing or altering the production of the protein product. MicroRNAs (miRNAs) are a class of small (~19–24 nucleotides in length), endogenous, evolutionarily conserved RNAs that function as posttranscriptional regulators of gene expression. MicroRNAs: Introduction and a Brief History |